Complications of diazoxide in the treatment of nesidioblastosis.
نویسنده
چکیده
Two children with hypoglycaemia secondary to hyperinsulinaemia were treated with diazoxide. They suffered serious side effects of cardiac failure and truncal ataxia.
منابع مشابه
Idiopathic hypoglycaemia in sibs with morphological evidence of nesidioblastosis of the pancreas.
Two sibs who sustained severe hypoglycaemia in the neonatal period are reported. In spite of treatment with frequent feeds intravenous glucose, glucagon, hydrocortisone, and diazoxide, hypoglycaemia persisted, and both infants eventually required subtotal pancreatectomy. Tests for leucine toleranct were normal though the second case showed some protein sensitivity. Histological and immunohistoc...
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A preterm female infant presented with intractable hypoglycaemia within 10 minutes of delivery. Normoglycaemia could be maintained only by the intravenous infusion of glucose at a rate of 20-22 mg/kg/min. Persistent hyperinsulinaemic hypoglycaemia of infancy was diagnosed from an inappropriately raised plasma insulin concentration (33 mU/l) at the time of hypoglycaemia (blood glucose < 0.5 mmol...
متن کاملIonic control of l cell function in nesidioblastosis . A possible therapeutic role for calcium channel blockade
Accepted 21 February 1996 Abstract A preterm female infant presented with intractable hypoglycaemia within 10 minutes of delivery. Normoglycaemia could be maintained only by the intravenous infusion of glucose at a rate of 20-22 mg/kg/min. Persistent hyperinsulinaemic hypoglycaemia ofinfancy was diagnosed from an inappropriately raised plasma insulin concentration (33 mU/l) at the time of hypog...
متن کاملNesidioblastosis coexisting with non-functioning islet cell tumour in an adult.
The most common cause of hyperinsulinaemic hypoglycaemia in adult is insulinoma. Although nesidioblastosis is a rare but well-recognized disorder of persistent hypoglycaemia in infants, it is extremely rare in adults.We present a case of a 59-year-old woman with small neuroendocrine tumour of the tail of the pancreas, diagnosed by CT scans and MRI, and hypoglycaemic syndrome. Laparoscopic dista...
متن کاملDiffuse nesidioblastosis with hypoglycemia mimicking an insulinoma: a case report
INTRODUCTION We describe a case of diffuse nesidioblastosis in an adult patient who presented with exclusively fasting symptoms and a focal pancreatic 111In-pentetreotide uptake mimicking an insulinoma. CASE PRESENTATION A 23-year-old Caucasian man had severe daily fasting hypoglycemia with glucose levels below 2mmol/L. Besides rare neuroglycopenic symptoms (confusion, sleepiness), he was lar...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 60 5 شماره
صفحات -
تاریخ انتشار 1985